PNOĒ's New Face Mask Wants to Make Lab-Grade Breath Testing a Self-Serve Affair
At first glance, the newest device from PNOĒ looks like something a comic-book villain might wear. The mask, which covers the nose and mouth and straps around the back of the head, bears more than a passing resemblance to the one worn by Bane, Batman's hulking nemesis. But its purpose is far more benign: it measures how much oxygen you consume and how much carbon dioxide you exhale, then turns that data into advice on how to eat, train, and—the company hopes—live longer.
PNOĒ, based in Malden, Massachusetts, with operations in Athens, Greece, is preparing to launch the PNOĒ 2.0 on October 1. The big change from its current device is that users can administer the test themselves. According to co-founder and CEO Apostolos Atsalakis, someone can walk into a gym, “just wear the mask, push the button, sit down,” and breathe for eight minutes. “That's it. It's that easy,” he said recently in a Zoom call from the company's Athens location.
That matters because PNOĒ's current device requires a trained operator, which limits where it can be used. A self-serve version could open the door to fitness centers without dedicated staff and potentially even pharmacies, Atsalakis said.
The Science Behind PNOĒ
The science behind PNOĒ isn't new. Metabolic testing, which analyzes the gases in a person's breath to gauge how their body produces energy, has been around for more than a century. For decades, it has been the gold standard for measuring VO₂ max—the maximum amount of oxygen the body can use during exercise and a widely used measure of cardiorespiratory fitness. But the tests have traditionally required bulky, expensive equipment found mainly in sports labs and hospitals, which is why they've largely been the province of elite athletes and executive wellness programs.
What 10-year-old PNOĒ promises is the same accuracy in a portable package, paired with software that translates the results into recommendations. “We made it accessible to everyone,” Atsalakis said.
The company says its test captures 23 biomarkers, including VO₂ max, resting metabolic rate (how many calories the body burns at rest), and metabolic flexibility (how well the body switches between burning fat and carbohydrates). Atsalakis argues that these metrics answer questions that blood tests can't, such as how many calories a person needs or how they should train.
Riding the Longevity Wave
The timing is good for PNOĒ. VO₂ max has become a buzzword among longevity enthusiasts, thanks in part to research linking higher cardiorespiratory fitness to lower mortality. Atsalakis calls VO₂ max the strongest predictor of human longevity, and he sees his company's data as a kind of scorecard for the booming wellness industry—a sector that, by 2026, is increasingly focused on quantifiable biomarkers and preventive health strategies.
Design and Hygiene
The new device is smaller and more compact than its predecessor, with fewer parts, which Atsalakis said makes it more reliable. It was designed with Milan-based Design Group Italia over what Atsalakis described as “a lot, a lot, a lot of iterations,” since a self-administered metabolic testing device hadn't been done before.
It also addresses a question that post-pandemic users are likely to ask: who wore it last? The answer: it doesn't matter, as the electronics detach from the silicone mask and straps, so multiple people can share the costly hardware while each user keeps their own mask.
Careful About Claims
For all its clinical ambitions, PNOĒ is careful about what it claims. The device isn't cleared by the U.S. Food and Drug Administration, and Atsalakis said that “we do not provide medical recommendations.” Instead, PNOĒ considers itself a wellness device. “It's like a body composition device, like a scale,” he said. “A doctor cannot prescribe medication based on our results.”
That could change down the road. Researchers have long explored whether compounds in human breath can signal disease, and as of 2026, breath-based diagnostics remain an active area of study. For now, PNOĒ is positioning itself as a tool for optimization, not diagnosis—a distinction that may help it navigate regulatory waters while still appealing to health-conscious consumers.
via TechCrunch